IntegratingChineseandWesternMedicineforthePreventionandTreatmentof COVID-19:ALivingEvidence-basedClinicalPracticeGuideline

Title: IntegratingChineseandWesternMedicineforthePreventionandTreatmentof COVID-19:ALivingEvidence-basedClinicalPracticeGuideline
Edition: Original
Classification: Traditional Chinese Medicine guideline
Field: Treatment
Countries and regions: China
Guidelines users: This guide can be applied to medical staff, public health staff, scientific research workers and community residents who diagnose and treat patients with COVID-19 pneumonia in fever clinics, emergency departments, intensive care departments, respiratory departments, integrated Chinese and Western medicine.
Evidence classification method: Based on the quality of evidence evaluated by the GRADE evaluation system and develops evidence summary table (including "Evidence Profile" and "Evidence to Decision (EtD) table"). When new evidence appears, the guideline evidence review group will update the above two tables in a timely manner, then form a living summary table to confirm new recommendations.
Development unit: 兰州大学
Registration time: 2020-10-29
Registration number: IPGRP-2020CN164
Purpose of the guideline: Since the outbreak of pneumonia caused by the novel coronavirus  (COVID-19), the number of people infected worldwide has been increasing. On August 1, 2020, the WHO issued a statement stating that the COVID-19 will continue to be a “public health emergency of international concern”. At present, there is still no specific medicine to treat COVID-19, and Vaccine development is also in clinical trials stage. Traditional Chinese medicine has fully demonstrated its characteristics and advantages in the treatment of COVID-19 , and can play a role throughout the process. In the currently published guidelines for the treatment of COVID-19 with traditional Chinese medicine/integrated traditional Chinese and Western medicine, due to factors such as early formulation and lack of direct clinical evidence, the recommendations are mostly based on the diagnosis and treatment plans issued by the country or provinces, or based on SARS, MARS and other respiratory diseases. Systematic disease-related studies are used as indirect evidence, and very few recommendations are based on direct evidence from clinical trials of the COVID-19. Living guidelines use the evidence monitoring system to continuously search for new evidence related to recommendations, incorporate them into the evidence summary, and quickly update the guidelines and recommendations when the evidence changes substantially, so as to create a real-time and continuously updated Evidence system. The development of dynamic systematic reviews and dynamic guidelines can promptly and effectively promote the best research evidence for clinical practice. Therefore, this living guideline is based on a living systematic review: the Treatment for Traditional Chinese Medicine of COVID-19: A Living Systematic Review and Meta-Analysis to develop a living guideline for the treatment and prevention of COVID-19 with integrated traditional Chinese and Western medicine.